TDCPP (Tris(1,3-dichloroisopropyl)phosphate) 13674-87-8 GlpBio

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Product Data Sheet

Product Name:Cat. No.:

TDCPP (Tris(1,3-dichloroisopropyl)phosphate)GC34128

Chemical Properties

Cas No.ChemicalNameCanonicalSMILESFormulaSolubilityGeneral tipsShippingCondition

13674-87-8N/A

O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CClC9H15Cl6O4P

DMSO : ≥ 62.5 mg/mL (145.05

mM);H2O : < 0.1 mg/mL (insoluble)

M.WtStorage

430.9Store at -20°C

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bathfor a while.Stock solution can be stored below -20℃ for several months.

Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice uponrequest.

Structure

Background

TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected

Caution: Producthasnot been fully validated for medical applications. For research use only.

Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com

Address: 10292 Central Ave. #205, Montclair, CA, USA

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Peptides, Inhibitors, Agonists

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Product Data Sheet

organophosphorus flame retardants (OPFRs) in the environment.

Exposure to TDCPP does not significantly affect cell viability until at concentration >68 μg/mL. HCECs show a 16%cell viability loss after exposing to 136 μg/mL TDCPP. Moreover, TDCPP induces a sharp decrease in viable cells(87%) after exposing to ≥272 μg/mL TDCPP. Based on cell viability, the LC50 value for TDCPP is 202 μg/mL using anonlinear regression. Compare to controls, TDCPP-exposed cells exhibit a concentration-dependent increase in

apoptosis. Anti-apoptotic Bcl-2 protein expression is increased to 1.4 fold after exposing to 2 μg/mL TDCPP, 1.2-foldsat 20 μg/mL but dynamically decreased to 0.4 fold at 200 μg/mL compare to control. The caspase-3 activity is

increased to 2.1 folds of the control at 200 μg/mL TDCPP[1]. TDCPP inhibits cell growth at lower concentrations (IC50of 27 μM), while cell viability and toxicity are affected at higher concentrations (IC50 of 171 μM and 168 μM,respectively)[2].

[1]. Xiang P, et al. Effects of organophosphorus flame retardant TDCPP on normal human corneal epithelial cells:Implications for human health. Environ Pollut. 2017 Nov;230:22-30. [2]. Killilea DW, et al. Flame retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) toxicity is attenuated by N-acetylcysteine in human kidney cells. Toxicol Rep.2017 May 17;4:260-264.

Caution: Producthasnot been fully validated for medical applications. For research use only.

Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com

Address: 10292 Central Ave. #205, Montclair, CA, USA

2www.glpbio.com