Xylazine hydrochloride_23076-35-9_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: CatNo:Cat. No.:MWt:Formula:Purity :Xylazine hydrochloride23076-35-9HY-B0443AHYB0443A256.79C12H17ClN2S>98%Solubility:DMSO50mg/mL;Water12mg/mLDMSO 50 mg/mL; Water 12 mg/mLMechanisms: Pathways:GPCR/G protein; Target:Adrenergic Receptor Biological Activity:Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.Target: Adrenergic Receptor Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animalssuch as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist atthe α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug,especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparentside effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaineinducedasimilardurationofanalgesiawithseverehindlimbataxia(100%incidence)Weinduced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). Weconcluded that xylazine given by epidural injection results in safe, effective perineal analgesia inhorses [...References:[1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its healthconsequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26. [2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blockingagents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92.tJPhlETh1981218(1)18892Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com